“Our approach uses a one-time application of very small amounts of two agents to stimulate the immune cells only within the tumor itself.
In the mice, we saw amazing, bodywide effects, including the elimination of tumors all over the animal.”.
Immune cells like T cells recognize the abnormal proteins often present on cancer cells and infiltrate to attack the tumor.
Levy’s method works to reactivate the cancer-specific T cells by injecting microgram amounts of two agents directly into the tumor site.
Because the two agents are injected directly into the tumor, only T cells that have infiltrated it are activated.
The approach worked startlingly well in laboratory mice with transplanted mouse lymphoma tumors in two sites on their bodies.
Finally, Sagiv-Barfi explored the specificity of the T cells by transplanting two types of tumors into the mice. »
