A cancer-killing virus has stopped pancreatic tumours from growing and spreading in three people in an initial safety trial, raising hopes that it may help to beat the deadly condition.
A scanning electron micrograph of pancreatic cancer cells ANNE WESTON, EM STP, THE FRANCIS CRICK INSTITUTE/SCIENCE PHOTO LIBRARY.
A virus has stopped pancreatic cancer in its tracks in three people in a clinical trial in the US.
One reason is that symptoms tend to appear late, when the cancer has already spread and cannot be surgically removed.
Immunotherapies that boost immune activity against cancer are also ineffective, because pancreatic tumours can hide from the immune system.
After cancer cells become infected with the virus, they burst open and die, releasing more virus that can infect neighbouring cancer cells.
However, it became clear that adenoviruses must be engineered to make them selectively target cancer cells, for safety and efficacy reasons. »