## Scientists Discover a Way to Silence the Gene That Keeps Cholesterol High, Cutting Bad Cholesterol by 50% Without a Single Statin

Authored by thefirmo.com

High cholesterol is one of its primary drivers, and the limitations of existing treatments have long been one of medicine’s most urgent unsolved problems.

These are short, single-stranded DNA molecules engineered to bind with precision to specific genetic sequences and effectively silence them.

The target is a protein called PCSK9, which has become one of the most important focal points in cholesterol research over the past decade.

PCSK9 works by attaching to LDL receptors on liver cells, the very receptors responsible for pulling bad cholesterol out of the bloodstream.

When PCSK9 levels are high, fewer receptors are available, and LDL cholesterol accumulates in the blood, clogging arteries and raising the risk of heart disease.

By silencing the gene that produces PCSK9, the new treatment effectively removes the block, allowing the liver to clear far more cholesterol from circulation.

The goal is the same as it has always been: lower bad cholesterol, protect the heart, and keep people alive longer. »

### South Korean judge who hiked ex-first lady's jail sentence found dead

Authored by japantimes.co.jp

A South Korean judge who more than doubled the former first lady's prison sentence last month was found dead on Wednesday, police said.

Shin Jong-o was "found unconscious around 1:00 a.m. ... at the Seoul High Court building," an investigator at Seocho district police station said.

Shin was taken to hospital and pronounced dead, he said, adding: "There is no sign of foul play in the death.". »

### He was teaching CPR, then went into cardiac arrest. His students saved him

Authored by cbc.ca

LISTEN | Full interview with EMT instructor Karl Arps and student Logan Lehrer: As It Happens 6:15 He was teaching CPR, then went into cardiac arrest.

Karl Arps was demonstrating the signs of a heart attack during a training course when he really had one, and went into cardiac arrest.

Logan Lehrer is one of the students who helped save an instructor's life when he went into cardiac arrest during a training simulation. »

### Former Elder Scrolls Online boss describes Tango Gameworks and Arkane Austin closing as a turning point at Xbox: 'I know where this is going'

Authored by pcgamer.com

To hear Firor tell it, the closure of Arkane Austin and Tango Gameworks on the same day was recognized as a sign of things to come inside Xbox.

Firor said that the presence of industry veterans at ZeniMax Online primed them to recognize this likely meant more hardship to come.

"[The Elder Scrolls Online team] was hundreds and hundreds of people by that point," said Firor. »

### Alleged suicide note written by Jeffrey Epstein unsealed by federal judge

Authored by theguardian.com

A federal judge unsealed an alleged suicide note written by Jeffrey Epstein on Wednesday, the first time the document has been made public.

View image in fullscreen The alleged Epstein suicide note.

The apparent suicide note had been sealed as a part of Tartaglione’s appeal case, due to attorney-client privilege. »

## In pictures

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