## Scientists inject one tumor and watch cancer vanish across the body

Authored by sciencedaily.com

For more than two decades, scientists have explored a group of cancer drugs known as CD40 agonist antibodies.

Early experiments suggested these treatments could strongly activate the immune system and help it destroy cancer cells.

Results from the phase 1 clinical trial of the modified drug, called 2141-V11, have now been published in the journal Cancer Cell.

The trial involved 12 people with several types of metastatic cancer, including melanoma, renal cell carcinoma, and different forms of breast cancer.

"The drug creates an immune microenvironment within the tumor, and essentially replaces the tumor with these tertiary lymphoid structures.".

"Once the immune system identifies the cancer cells, immune cells migrate to the non-injected tumor sites," Osorio explains.

Current phase 1 and phase 2 trials are testing 2141-V11 against several difficult-to-treat cancers, including bladder cancer, prostate cancer, and glioblastoma. »

### Jensen Huang says gamers are 'completely wrong' about DLSS 5 — Nvidia CEO responds to DLSS 5 backlash

Authored by tomshardware.com

Much of the criticism has focused on the updated appearances of Resident Evil Requiem's Grace Ashcroft and Leon Kennedy.

"Well, first of all, they're completely wrong," Huang said in response to a question from Tom's Hardware editor-in-chief Paul Alcorn about the criticism.

We'll see if the vocal gamers who say they dislike what they see change their mind as we see more. »

### World Health Organization Prepares for Nuclear Scenario, Including Weapons Use, in Iran — UNITED24 Media

Authored by united24media.com

The World Health Organization (WHO) is preparing for the possibility of a nuclear-related incident as tensions continue to escalate in the Middle East, including scenarios involving strikes on nuclear facilities or the potential use of nuclear weapons.

The organization is updating internal protocols and guidance for staff and governments on how to respond in the event of a nuclear emergency.

The organization referenced past nuclear events, including the Chornobyl disaster and the atomic bombings of Hiroshima and Nagasaki, as examples of long-term consequences. »

### Jonathan Powell on Iran Deal Progress Before Conflict

Authored by storiestoday.co.uk

Sources indicate that Powell was taken aback by the scope of Iran’s offer, which he believed would undermine the immediate military action.

And his assessment, shared with the Cabinet Office just days before the first missiles flew, was clear: a deal was “within touching distance.”

For years, the sticking point with Iran has been “sunset clauses”—the idea that restrictions eventually expire. »

### Ukraine Drones Wipe Out Most Tanks at Key Russian Military Fuel Depot in Krasnodar

Authored by kyivpost.com

As a result, 18 of the 20 storage tanks burned – including 9 gasoline and 9 diesel tanks - as well as 7 fuel tankers.

According to Russian media, the Labinsk oil depot belongs to Yugnefteprodukt and is one of the largest in the region.

The region is considered a key logistics hub for the Russian military, with oil depots serving as “gas stations” for troops in southern Ukraine. »

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