The Daily Populous Thursday January 29th, 2026 morning edition
Authored by euronews.com and submitted by zek_997

Pancreatic cancer is one of the most aggressive tumours with the worst prognosis, partly because of the rapid emergence of resistance to treatment. But a new study from the Spanish National Cancer Research Centre (CNIO) reveals that it is possible to eliminate pancreatic tumours in mice and prevent them from recurring using triple combination therapy.

"These studies open a way to design new combination therapies that can improve the survival of patients with pancreatic ductal adenocarcinoma," the authors said in a statement. "These results set the direction for the development of new clinical trials, it added.

The results, published in the scientific journal 'PNAS', show that simultaneously targeting three key points of the KRAS oncogene molecular pathway achieves long-lasting tumour regression. In Spain, more than 10,300 cases of this type of cancer are diagnosed each year, with a five-year survival rate of less than 10 percent.

The key to the breakthrough lies in avoiding the resistance that appears when the oncogene is blocked at a single point. The CNIO team combined an experimental KRAS inhibitor, a drug already approved for lung cancer, with a protein degrader, resulting in tumours disappearing without significant side effects in three different animal models.

Although the result could be a milestone in the fight against cancer, the study authors issued caution.

"We are not yet in a position to carry out clinical trials with triple therapy. The authors themselves warn that optimising this combination for patients will be a complex process, although they are confident that the finding will set the course for future trials," they said.

Vizth on January 28th, 2026 at 20:42 UTC »

Lost my dad to this. It also runs in the family and there is a good chance I'll be joining him the same way, I'm only a year younger than he was now.

Any news of a breakthrough is welcome.

ILostMyParadise on January 28th, 2026 at 20:26 UTC »

My aunt is dying from this right now, has a couple of weeks left at most. Horrible horrible horrible disease.

CharcoalGreyWolf on January 28th, 2026 at 18:12 UTC »

I lost my spouse to this.

I would really like to see a significant breakthrough for it in my lifetime; it’s a horrible disease. The five year survival rate is 19%, it’s rarely caught early (symptoms often don’t show until Stage 4), and if it isn’t, it’s pretty much a death sentence.