The Daily Populous

Saturday July 26th, 2025 evening edition

image for Scientists Find 2 Existing Drugs Can Reverse Alzheimer's Brain Damage in Mice

Researchers from the University of California, San Francisco (UCSF) and Gladstone Institutes started by looking at how Alzheimer's altered gene expression in the brain.

"We're excited that our computational approach led us to a potential combination therapy for Alzheimer's based on existing FDA-approved medications.".

Having picked out letrozole and irinotecan as the best candidates, the researchers tested them in mouse models of Alzheimer's.

When used in tandem, the drugs were shown to reverse some of the brain changes brought on by the disease.

By combining the two drugs together, the researchers were able to target different types of brain cells affected by the disease.

Finding ways to prevent the disease and even reverse symptoms would have a huge impact on global health.

"We're hopeful this can be swiftly translated into a real solution for millions of patients with Alzheimer's.". »

Gabbard and White House 'lying' about intel on Russian interference in 2016, ex-CIA official says

Authored by nbcnews.com
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“The director of national intelligence and the White House are lying, again,” Miller said.

“We definitely had the intel to show with high probability that the specific goal of the Russians was to get Trump elected.”.

Gabbard, current CIA Director John Ratcliffe and the White House have accused Brennan of fabricating intelligence about the 2016 election to undermine Trump. »

Family sues after funeral home sends son’s brain in unmarked leaking box

Authored by theguardian.com
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At Nix & Nix Funeral Homes, Abbey Butler tried but could not open the red box, said the Butlers’ attorney, L Chris Stewart, at the news conference.

Several days later, the red box, which was in the Butlers’ car, began to smell and leak fluid, Stewart said.

Nix told local news that his team believed the box held personal effects and that other funeral homes usually only send intact remains. »

Games Industry Could Be Worth $300 Billion In 4 Years, Report Suggests

Authored by gamespot.com

A report from analysts at the PwC network has predicted that video games will be a major source of growth for the broader entertainment and media industry in the next few years, with the firm calling gaming "an industry bright spot" in times of economic uncertainty.

The PwC report suggests that the games industry, which saw total revenues of $224 billion in 2024, could grow to nearly $300 billion by 2029.

Another recent report suggested 4 billion people, around half the world's population, would be counted as gamers by 2028. »

Elden Ring's DLC has moved over 10 million copies, and Nightreign's already on 5 million sold

Authored by pcgamer.com

Bandai Namco has announced that the Elden Ring expansion Shadow of the Erdtree has sold 10 million copies.

This follows hot on the heels of the news that Elden Ring itself has now sold over 30 million copies, and the tills just don't stop ringing in the Lands Between: the multiplayer spinoff title Elden Ring Nightreign, which released on 30 May, has sold five million.

As for Nightreign, yep, also brutally difficult, though in this case it may just be my wizened reflexes that can't keep up. »