Brand, who was born in Essex, rose to fame as a stand-up comedian, performing at the Hackney Empire in 2000 and later the Edinburgh Fringe.
He later moved into broadcasting, hosting national television and radio programmes.
The turning point in his career came in the mid-2000s, when he hosted Big Brother's Big Mouth, a companion show to the hugely popular reality series Big Brother.
It provided the springboard he was looking for and led to him becoming one of the most sought-after presenters in the UK.
Brand went on to host the NME, MTV and Brit awards ceremonies, had his own debate series by E4, and fronted the UK leg of charity concert Live Earth.
But he was never far away from controversy, particularly at awards ceremonies - which provided the kind of live, anything-can-happen chaos where he was most at home.
His career included hosting radio shows on the BBC, in particular for 6 Music and Radio 2, between 2006 and 2008.
But inappropriate phone calls he made to the Fawlty Towers actor Andrew Sachs during a show in 2008 prompted a huge scandal - and ultimately led to his dismissal.
He rebounded with a Hollywood career, starring in films like Forgetting Sarah Marshall and Get Him To The Greek.
Recent years have seen him take a new direction - particularly since the start of the Covid pandemic in 2020.
Brand grew his following on YouTube as he discussed scepticism surrounding the disease.
He has developed a cult following for his views on politics and society, through videos which challenge the mainstream reporting of a range of subjects and often amplify conspiracy theories. He has also established himself as a wellness guru.
Ramy__B on April 4th, 2025 at 13:47 UTC »
Yeah that's why he became super Christian all of a sudden. He knew this was coming
SomeDEGuy on April 4th, 2025 at 13:46 UTC »
This is the least surprising news story I've seen all week.
CrayonLunch on April 4th, 2025 at 13:43 UTC »
It's always the ones you most suspect