## Breakthrough ecDNA discovery could revolutionize cancer research

Authored by techspot.com

This kind of "external" oncogenes make cancer drug-resistant, and it could become one of the main targets for new and effective treatments in the future.

Extrachromosomal DNA, or ecDNA, is a piece of genetic material found outside of chromosomes in human cells.

Chromosomes are the main repository for normal genetic material, providing instructions on how to behave, function or reproduce to the aforementioned cells.

A team of chemists, biologists, geneticists, mathematicians, and immunologists from California, UK and research centers in other parts of the world has discovered the fundamental role played by ecDNA in the spread and relapse of cancer.

The secret recipe for cancer spreading, as it turns out, is that oncogenes hide within ecDNA before becoming active again.

The team of scientists received funding from the Cancer Grande Challenges initiative, a UK-registered charity created to promote progress in the global research against some of cancer's "toughest challenges."

Now that ecDNA has been identified as a fundamental element for cancer research, scientists think they will have a lot of work to do in the coming years. »

### Fallout: New Vegas’s lead writer has re-joined Obsidian, but insists it’s not for a sequel

Authored by videogameschronicle.com

The lead writer of Fallout: New Vegas has returned to developer Obsidian, after 14 years away from the company.

John Gonzalez announced the news on his LinkedIn profile this week, confirming he’s taken up the role of creative director.

After his previous stint at Obsidian in 2008 – 2011, Gonzalez was notably a writer for Monolith’s Middle-Earth: Shadow of Mordor, the lead writer for Guerrilla’s Horizon: Zero Dawn, and narrative director for its sequel Forbidden West. »

### Acting on Trump’s order, federal officials opened up two California dams

Authored by latimes.com

Pawlik said the Army Corps was releasing water from the dams “to ensure California has water available to respond to the wildfires.”

Trump, meanwhile, shared a photo on X of water pouring from a dam, saying: “Photo of beautiful water flow that I just opened in California.”.

It was not clear where federal officials intended to send the water that was being released from the dams. »

### Trump’s disregard for US constitution ‘a blitzkrieg on the law’, legal experts say

Authored by theguardian.com

Tribe said Trump has carried out “a blitzkrieg on the law and the constitution.

“A stunning number of his executive actions clearly violate the constitution and federal law,” Chemerinsky said.

“I cannot think of any president who has ever so ignored the constitution as extensively in the first 10 days of office as this. »

### Pentagon removes major media outlets, including NBC News, from dedicated workstations as part of a new 'rotation program'

Authored by nbcnews.com

In addition to NBC News, The New York Times, National Public Radio and Politico must vacate their dedicated workspaces.

In a statement, NBC News said, “We’re disappointed by the decision to deny us access to a broadcasting booth at the Pentagon that we’ve used for many decades.

The move by Pentagon officials comes seven days after the Senate confirmed Defense Secretary Pete Hegseth by the narrowest of margins. »

## In pictures

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