The Daily Populous Thursday April 4th, 2024 day edition
Authored by mirror.co.uk and submitted by daily_mirror

The UK is the only country performing keyhole eye surgery to inject healthy copies of a gene into sufferers’ eyes and is being used to reverse blindness in children born with a rare condition which means they can only distinguish between light and dark

A three year old with a genetic condition that causes blindness is doing incredibly well after unique pioneering operation to restore her sight.

The UK is the only country performing keyhole eye surgery to inject healthy copies of a gene into sufferers’ eyes. It is being used to reverse blindness in children born with a rare condition which means they can only distinguish between light and dark. And it has given little Khadijah Chaudhry, born with Leber congenital amaurosis-4, a chance at seeing properly again. The condition affects about one in 40,000 babies and causes cells in the retina to die off by the age of four.

Khadijah’s dad, Muhammad Muddassir, said: “Khadijah was just two years old when she was diagnosed. When she was a baby, we noticed she was moving her eyes abnormally, and her vision was slowly deteriorating over time. She still had some functional vision, and could play and walk independently but always supervised.

“Her eyesight was affecting her confidence and having her parents around reassured her, as her confidence dipped when she was by herself.”

Muhammad, Khadijah and mum Hafiza travelled from Hull to the Evelina London Children’s Hospital, part of St Thomas’ Hospital in London, which is the only hospital in the world carrying out the revolutionary gene therapy.

It was developed at University College London and Moorfields Eye Hospital and is performed by a team of Britain’s top eye experts, including from Moorfields and Great Ormond Street Hospital. Khadijah had both her eyes injected with the pioneering treatment, in two separate procedures. The operations took around one hour each to complete.

Muhammad added: “We were really pleased to hear this treatment was on offer. Following several investigations at Moorfields Eye Hospital and Evelina London, we found out that Khadijah was eligible, which was great news. Both of her procedures went well, and we’re optimistic to see how she progresses now with the treatment. The clinical team seem pleased with how they went, which is reassuring.”

The technique is so new, it is not yet licenced for general use. More data is collected on its long-term effectiveness. Lead surgeon Neruban Kumaran said: “We’re really pleased with how Khadijah’s surgeries went. Her mother and father have already noticed an improvement in her vision, which is very promising.”

HerbaciousTea on April 3rd, 2024 at 22:34 UTC »

There have been massive advances in gene therapy treatments in the past few years, from the incremental work of building more comprehensive libraries of genomes to new vectors for delivering the genes without the need to involve viral agents. The entire field is rapidly becoming vastly more well understood, safe, and reliable.

It is incredibly exciting to see treatments like this happening in practice more and more.

WeedWingsSpicyThings on April 3rd, 2024 at 17:29 UTC »

I really wish the title would have said “giving her a future she can look forward to”

daily_mirror on April 3rd, 2024 at 14:42 UTC »

A three year old with a genetic condition that causes blindness is doing incredibly well after unique pioneering operation to restore her sight. The UK is the only country performing keyhole eye surgery to inject healthy copies of a gene into sufferers’ eyes.

It is being used to reverse blindness in children born with a rare condition which means they can only distinguish between light and dark.

And it has given little Khadijah Chaudhry, born with Leber congenital amaurosis-4, a chance at seeing properly again. The condition affects about one in 40,000 babies and causes cells in the retina to die off by the age of four.

Khadijah’s dad, Muhammad Muddassir, said: “Khadijah was just two years old when she was diagnosed. When she was a baby, we noticed she was moving her eyes abnormally, and her vision was slowly deteriorating over time. She still had some functional vision, and could play and walk independently but always supervised.“Her eyesight was affecting her confidence and having her parents around reassured her, as her confidence dipped when she was by herself.”

The technique is so new, it is not yet licenced for general use. More data is collected on its long-term effectiveness. Lead surgeon Neruban Kumaran said: “We’re really pleased with how Khadijah’s surgeries went. Her mother and father have already noticed an improvement in her vision, which is very promising.”

https://www.mirror.co.uk/news/health/miracle-operation-reverses-blindness-three-32482156