Friends star Matthew Perry's death was an accident from the "acute effects of ketamine", a post-mortem has found.
Perry, who was best known for playing wise-cracking Chandler Bing in Friends, was found unresponsive in the swimming pool at this home on 28 October and pronounced dead at the age of 54 by paramedics at the scene.
Other contributing factors to his death included drowning, coronary artery disease and the effects of buprenorphine, which can be used to treat opioid use disorder, the post-mortem said.
Ketamine is a sedative that can be used to treat depression.
A report from the Los Angeles Department of Medical Examiner stated that Perry was "receiving ketamine infusion therapy for depression and anxiety" with the most recent dose reportedly taken one and a half weeks before his death.
The report continued: "The ketamine in his system at death could not be from that infusion therapy, since ketamine's half-life is three-to-four hours, or less."
Image: Perry with Friends co-stars Lisa Kudrow, Courteney Cox and Jennifer Aniston
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Perry appeared in the hit US show, which is set in New York between 1994 and 2004.
Tributes poured in for Perry in the days after his death, including from his co-stars.
What is ketamine? The post-mortem reports states that ketamine is a "dissociative anaesthetic with established human medical and surgical uses". Originally designed as an anaesthetic and tranquilliser, often used on horses during veterinary surgery, ketamine was banned as a recreational drug in 2006 and in now class B. It reduces sensations in the body and gives users a "floating" feeling but can also cause hallucinations, confusion, panic attacks and depression. It wasn't until the 90s that ketamine started to be widely used by young people involved in the dance music scene. It is used orally in tablet form, intra-nasally as a powder, or intravenously and intramuscularly as a liquid. Ketamine can also work as an antidepressant but has not been licensed for this use in the UK.
Friends actors Matt LeBlanc, Jennifer Aniston, Courteney Cox, David Schwimmer and Lisa Kudrow, were also among the 20 mourners at Perry's funeral in the Hollywood Hills in November.
Perry was open about his battle with substance abuse and addiction, and set up a sober living facility for men with similar issues.
A foundation has now been set up to help others struggling with the disease in his memory.
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Aniston, who played Rachel Green in the sitcom, was among those urging support of the foundation which was set up to "honour his legacy".
Perry's cause of death comes days after Aniston revealed she had been messaging him on the morning of his death, describing him as "happy and healthy".
"I want people to know he was really healthy, and getting healthy. He was on a pursuit. He worked so hard. He really was dealt a tough one," she told Variety.