Girl, 13, with incurable cancer recovers after pioneering treatment in London

Authored by metro.co.uk and submitted by umatbru

Little Alyssa became the first person in the world to be cured from leukaemia using the revolutionary technology (Picture: PA)

A girl’s incurable cancer has been cleared from her body after what scientists have described as the most sophisticated cell engineering to date.

Alyssa, whose family do not wish to give their surname, was diagnosed with T-cell acute lymphoblastic leukaemia in May 2021.

After a round of chemotherapy and a bone marrow transplant failed to rid the 13-year-old of the disease, doctors told her parents there was nothing more they can do.

Her only next step would have been palliative care, but instead, Alyssa decided to undergo an experimental new treatment.

Scientists at Great Ormond Street Hospital for Children in London gave her pre-manufactured cells edited using new technology to allow them to hunt down and destroy cancerous T-cells without attacking each other.

T-cells are a type of white blood cell which move around the body to find and kill defective cells.

This is the world’s first such treatment, and Alyssa’s recovery will give hope to tens of thousands of patients.

28 days after being given the treatment, Alyssa was in remission (Picture: PA)

The girl said she felt that taking the experimental treatment for the disease would help others, adding ‘of course I’m going to do it’.

Less than a month after being given the treatment, she was in remission, and was able to have a second bone marrow transplant.

She is said to be ‘doing well at home’ as she recovers and continues with follow-up monitoring.

He mum, Kiona, said the family were ‘on a strange cloud nine’, adding that it was ‘amazing to be home’.

She is now recovering at home and is still being monitored by doctors (Picture: PA)

She added: ‘Hopefully, this can prove the research works and they can offer it to more children – all of this needs to have been for something.’

Scientists now aim to recruit up to 10 patients who have T-cell leukaemia, just like Alyssa, and have exhausted all conventional options for the clinical trial into the new treatment.

They hope that if it is successful it can be offered to children earlier, when they are less sick, and that it can be used for other types of leukaemia in future.

Potential patients for trials will be referred by NHS specialists.

Professor Waseem Qasim, consultant immunologist at GOSH, said: ‘This is a great demonstration of how, with expert teams and infrastructure, we can link cutting-edge technologies in the lab with real results in the hospital for patients.

‘It’s our most sophisticated cell engineering so far and paves the way for other new treatments and ultimately better futures for sick children.

‘We have a unique and special environment here at GOSH that allows us to rapidly scale up new technologies and we’re looking forward to continuing our research and bringing it to the patients who need it most.’

Get in touch with our news team by emailing us at [email protected].

For more stories like this, check our news page.

allwhitebuffies on January 14th, 2023 at 02:05 UTC »

Something similar happened to my uncle. His expiration date was like 8 years ago. He recently almost died from some freak bug bite in Australia, they thought he had a week or so left. That was months ago and he's out of a coma and doing pretty well now. The man has 9 lives.

cash4chaos on January 14th, 2023 at 01:51 UTC »

Happy for this little girl! I was diagnosed with stage 4 CTCl lymphoma, Sezary Syndrome in 2020. I had a new drug called Brentuximab it saved my life! All scientists that work on these amazing new drugs thank you!

darthearljones on January 14th, 2023 at 00:37 UTC »

Fuck yeah science!