Just Stop Oil activists have thrown tomato soup over Van Gogh's masterpiece Sunflowers at the National Gallery.
Two women walked into a room at the gallery in London's Trafalgar Square at about 11am, the campaign group said.
They threw the contents of two tins of Heinz tomato soup over the famous 1888 painting, which has an estimated value of £72.5m.
Police arrested two people for criminal damage and aggravated trespass.
The National Gallery said there is "minor damage" to the frame of the painting, but the work is "unharmed" and is now back on display.
A video shows the two women wearing Just Stop Oil T-shirts gluing one hand each to the wall below the painting, which is protected by a pane of glass.
One of the climate change activists, 21-year-old Phoebe Plummer, then shouted: "What is worth more? Art or life?
Friday is the 14th day of demonstrations linked to the group - which wants the government to stop issuing all new oil and gas licences.
The group's activists have been blocking roads around parliament and elsewhere in London in the last few days.
Last Sunday, police said that more than 100 people had been arrested after a weekend of protest-related activity by
During the protest at the National Gallery, Ms Plummer said: "Are you more concerned about the protection of a painting? Or the protection of our planet and people?
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"The cost of living crisis is part of the cost of oil crisis.
"Fuel is unaffordable to millions of cold hungry families. They can't even afford to heat a tin of soup," she added, brandishing a tin.
Gasps and exclamations of "oh my gosh!" and "security" rang out from onlookers as the soup hit the painting. Visitors were quickly escorted out by security, who then shut the doors to room 43 of the gallery where the painting hangs.
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hanr86 on October 14th, 2022 at 15:18 UTC »
Before yall go crazy, the painting had a pane of glass over it guys.
pdevo on October 14th, 2022 at 11:24 UTC »
These new Heinz guerrilla marketing campaigns are taking things a little too far.
Naamibro on October 14th, 2022 at 10:48 UTC »
Please tell me it's behind some glass.