Gathering on London's Embankment, protesters marched past the Parliament buildings and through Oxford Street as they chanted "Free Palestine" and demanded an end to Israel's occupation.
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Some protesters lit flares showing the colours of the Palestinian flag as they gathered in the capital's iconic Trafalgar Square, chanting "Palestine will be free".
Organisers, including the Palestine Solidarity Campaign and Friends of Al-Aqsa, estimated that at least 180,000 people attended the London demonstration, making it the largest pro-Palestine protest in British history.
Israeli forces continue to bar Palestinian protesters from entering the Sheikh Jarrah neighbourhood of Jerusalem, where residents face possible expulsion from their homes.
However, pro-Israeli protesters continue to be let into the Sheikh Jarrah area, according to human rights observers.
The UN's Central Emergency Response Fund said it had released $18.5m for humanitarian efforts. »