An international team of researchers led by King’s and Erasmus University Medical Center Rotterdam have identified 50 new genes for eye colour in the largest genetic study of its kind to date. The study, published today in Science Advances, involved the genetic analysis of almost 195,000 people across Europe and Asia.
These findings will help to improve the understanding of eye diseases such as pigmentary glaucoma and ocular albinism, where eye pigment levels play a role.
In addition, the team found that eye colour in Asians with different shades of brown is genetically similar to eye colour in Europeans ranging from dark brown to light blue.
This study builds on previous research in which scientists had identified a dozen genes linked to eye colour, believing there to be many more. Previously, scientists thought that variation in eye colour was controlled by one or two genes only, with brown eyes dominant over blue eyes.
Co-senior author Dr Pirro Hysi, King’s, said: “The findings are exciting because they bring us to a step closer to understanding the genes that cause one of the most striking features of the human faces, which has mystified generations throughout our history. This will improve our understanding of many diseases that we know are associated with specific pigmentation levels.”
Co-senior author Dr Manfred Kayser, Erasmus University Medical Center Rotterdam, said: “This study delivers the genetic knowledge needed to improve eye colour prediction from DNA as already applied in anthropological and forensic studies, but with limited accuracy for the non-brown and non-blue eye colours.”
SureFudge on March 16th, 2021 at 16:38 UTC »
Fun Fact: My GFs eye color changed during pregnancy, from blue to green. Permanently. So hormones seems to play some crucial role too. Kid still has blue eyes (now 3 years old so seems like it will stay that way).
SomeoneNamedSomeone on March 16th, 2021 at 16:29 UTC »
In case it wasn't clear what changed.
In earliest model (and what you are taught in High School), eye colour is a trait that is purely Mendelian inheritance. Autosomal Dominant and Autosomal Recessive.
Next level discovered that at least 8 genes are responsible for eye colour (which is what most Uni courses would have told you).
Now, at least 50 are known to be directly and indirectly responsible for eye colour.
Thats the TLDR of what changed
FerociousFrizzlyBear on March 16th, 2021 at 16:13 UTC »
I’ve always thought that eye color was a terrible example for school biology classes to use for their Punnett square lessons. Eye color is controlled by more than one gene (and now we know there are even more than previously thought!) and yet so many people grow up thinking that two blue eyed people could never have children with any eye color other than blue.