The news comes as she continues her quest to give away much of her wealth since her $38 billion divorce settlement with Bezos.
In a new Medium post, Scott, who has a net worth topping $60 billion, announced the nearly $4.2 billion in donations to organizations ranging from food banks to emergency relief funds.
The news comes after announcing back in July that she'd already given $1.7 billion to 114 organizations over the past year.
As previously reported by Business Insider, the world's richest have seen their net worths skyrocket by nearly $1 trillion amid the pandemic.
Scott is no exception, with Bloomberg reporting that her wealth increased by $23.6 billion this year, primarily due to her shares in Amazon, which saw a surge.
Chuck Collins, the director of the Program on Inequality and the Common Good at the Institute for Policy Studies (IPS), endorsed Scott's latest donation.
"MacKenzie Scott's bold and direct giving puts shame to the billionaire class and their perpetual private foundations," he said in a statement. »