Woman with ‘mutant’ gene who feels no pain and heals without scarring discovered by scientists

Authored by independent.co.uk and submitted by Sariel007

A good-natured Scottish pensioner who experiences virtually no pain has superhuman healing and remains unflappable in life-threatening situations may sound like a Marvel spin-off but has just been reported in a leading scientific journal.

UK researchers have discovered Jo Cameron's, now 71, remarkable abilities are apparently down to a previously unreported genetic mutation.

The case, published in the British Journal of Anaesthesia, could open the door for a host of new treatments to help people recover from surgery, manage chronic pain and anxiety disorders.

We’ll tell you what’s true. You can form your own view. From 15p €0.18 $0.18 USD 0.27 a day, more exclusives, analysis and extras.

Ms Cameron first caught doctors attention when, aged 65, she sought treatment for a hip problem, which doctors later found to be severely arthritic and needed replacing.

The discomfort would usually have been debilitating and after a second painless surgery doctors at Raigmore Hospital, Inverness, decided it needed further investigating.

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Italian researchers found women living in the most polluted areas were three times more likely to show signs they were running low on eggs than those who lived in cleaner surroundings, potentially triggering an earlier menopause Getty/iStock 3/47 Two hours a week spent in nature can improve health A study in the journal Scientific Reports suggests that a dose of nature of just two hours a week is associated with better health and psychological wellbeing Shutterstock 4/47 Junk food ads could be banned before watershed Junk food adverts on TV and online could be banned before 9pm as part of Government plans to fight the "epidemic" of childhood obesity. Plans for the new watershed have been put out for public consultation in a bid to combat the growing crisis, the Department of Health and Social Care (DHSC) said PA 5/47 Breeding with neanderthals helped humans fight diseases On migrating from Africa around 70,000 years ago, humans bumped into the neanderthals of Eurasia. While humans were weak to the diseases of the new lands, breeding with the resident neanderthals made for a better equipped immune system PA 6/47 Cancer breath test to be trialled in Britain The breath biopsy device is designed to detect cancer hallmarks in molecules exhaled by patients Getty 7/47 Average 10 year old has consumed the recommended amount of sugar for an adult By their 10th birthdy, children have on average already eaten more sugar than the recommended amount for an 18 year old. The average 10 year old consumes the equivalent to 13 sugar cubes a day, 8 more than is recommended PA 8/47 Child health experts advise switching off screens an hour before bed While there is not enough evidence of harm to recommend UK-wide limits on screen use, the Royal College of Paediatrics and Child Health have advised that children should avoid screens for an hour before bed time to avoid disrupting their sleep Getty 9/47 Daily aspirin is unnecessary for older people in good health, study finds A study published in the New England Journal of Medicine has found that many elderly people are taking daily aspirin to little or no avail Getty 10/47 Vaping could lead to cancer, US study finds A study by the University of Minnesota's Masonic Cancer Centre has found that the carcinogenic chemicals formaldehyde, acrolein, and methylglyoxal are present in the saliva of E-cigarette users Reuters 11/47 More children are obese and diabetic There has been a 41% increase in children with type 2 diabetes since 2014, the National Paediatric Diabetes Audit has found. Obesity is a leading cause Reuters 12/47 Most child antidepressants are ineffective and can lead to suicidal thoughts The majority of antidepressants are ineffective and may be unsafe, for children and teenager with major depression, experts have warned. In what is the most comprehensive comparison of 14 commonly prescribed antidepressant drugs to date, researchers found that only one brand was more effective at relieving symptoms of depression than a placebo. Another popular drug, venlafaxine, was shown increase the risk users engaging in suicidal thoughts and attempts at suicide Getty 13/47 Gay, lesbian and bisexual adults at higher risk of heart disease, study claims Researchers at the Baptist Health South Florida Clinic in Miami focused on seven areas of controllable heart health and found these minority groups were particularly likely to be smokers and to have poorly controlled blood sugar iStock 14/47 Breakfast cereals targeted at children contain 'steadily high' sugar levels since 1992 despite producer claims A major pressure group has issued a fresh warning about perilously high amounts of sugar in breakfast cereals, specifically those designed for children, and has said that levels have barely been cut at all in the last two and a half decades Getty 15/47 Potholes are making us fat, NHS watchdog warns New guidance by the National Institute for Health and Care Excellence (NICE), the body which determines what treatment the NHS should fund, said lax road repairs and car-dominated streets were contributing to the obesity epidemic by preventing members of the public from keeping active PA 16/47 New menopause drugs offer women relief from 'debilitating' hot flushes A new class of treatments for women going through the menopause is able to reduce numbers of debilitating hot flushes by as much as three quarters in a matter of days, a trial has found. The drug used in the trial belongs to a group known as NKB antagonists (blockers), which were developed as a treatment for schizophrenia but have been “sitting on a shelf unused”, according to Professor Waljit Dhillo, a professor of endocrinology and metabolism REX 17/47 Doctors should prescribe more antidepressants for people with mental health problems, study finds Research from Oxford University found that more than one million extra people suffering from mental health problems would benefit from being prescribed drugs and criticised “ideological” reasons doctors use to avoid doing so. Getty 18/47 Student dies of flu after NHS advice to stay at home and avoid A&E The family of a teenager who died from flu has urged people not to delay going to A&E if they are worried about their symptoms. Melissa Whiteley, an 18-year-old engineering student from Hanford in Stoke-on-Trent, fell ill at Christmas and died in hospital a month later. 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Wikimedia Commons / Nephron 22/47 Babies' health suffers from being born near fracking sites, finds major study Mothers living within a kilometre of a fracking site were 25 per cent more likely to have a child born at low birth weight, which increase their chances of asthma, ADHD and other issues Getty 23/47 NHS reviewing thousands of cervical cancer smear tests after women wrongly given all-clear Thousands of cervical cancer screening results are under review after failings at a laboratory meant some women were incorrectly given the all-clear. A number of women have already been told to contact their doctors following the identification of “procedural issues” in the service provided by Pathology First Laboratory. Rex 24/47 Potential key to halting breast cancer's spread discovered by scientists Most breast cancer patients do not die from their initial tumour, but from secondary malignant growths (metastases), where cancer cells are able to enter the blood and survive to invade new sites. Asparagine, a molecule named after asparagus where it was first identified in high quantities, has now been shown to be an essential ingredient for tumour cells to gain these migratory properties. Getty 25/47 NHS nursing vacancies at record high with more than 34,000 roles advertised A record number of nursing and midwifery positions are currently being advertised by the NHS, with more than 34,000 positions currently vacant, according to the latest data. Demand for nurses was 19 per cent higher between July and September 2017 than the same period two years ago. 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Getty 27/47 Over 75,000 sign petition calling for Richard Branson's Virgin Care to hand settlement money back to NHS Mr Branson’s company sued the NHS last year after it lost out on an £82m contract to provide children’s health services across Surrey, citing concerns over “serious flaws” in the way the contract was awarded PA 28/47 More than 700 fewer nurses training in England in first year after NHS bursary scrapped The numbers of people accepted to study nursing in England fell 3 per cent in 2017, while the numbers accepted in Wales and Scotland, where the bursaries were kept, increased 8.4 per cent and 8 per cent respectively Getty 29/47 Landmark study links Tory austerity to 120,000 deaths The paper found that there were 45,000 more deaths in the first four years of Tory-led efficiencies than would have been expected if funding had stayed at pre-election levels. On this trajectory that could rise to nearly 200,000 excess deaths by the end of 2020, even with the extra funding that has been earmarked for public sector services this year. Reuters 30/47 Long commutes carry health risks Hours of commuting may be mind-numbingly dull, but new research shows that it might also be having an adverse effect on both your health and performance at work. Longer commutes also appear to have a significant impact on mental wellbeing, with those commuting longer 33 per cent more likely to suffer from depression Shutterstock 31/47 You cannot be fit and fat It is not possible to be overweight and healthy, a major new study has concluded. The study of 3.5 million Britons found that even “metabolically healthy” obese people are still at a higher risk of heart disease or a stroke than those with a normal weight range Getty 32/47 Sleep deprivation When you feel particularly exhausted, it can definitely feel like you are also lacking in brain capacity. Now, a new study has suggested this could be because chronic sleep deprivation can actually cause the brain to eat itself Shutterstock 33/47 Exercise classes offering 45 minute naps launch David Lloyd Gyms have launched a new health and fitness class which is essentially a bunch of people taking a nap for 45 minutes. The fitness group was spurred to launch the ‘napercise’ class after research revealed 86 per cent of parents said they were fatigued. The class is therefore predominantly aimed at parents but you actually do not have to have children to take part Getty 34/47 'Fundamental right to health' to be axed after Brexit, lawyers warn Tobacco and alcohol companies could win more easily in court cases such as the recent battle over plain cigarette packaging if the EU Charter of Fundamental Rights is abandoned, a barrister and public health professor have said. Getty 35/47 'Thousands dying' due to fear over non-existent statin side-effects A major new study into the side effects of the cholesterol-lowering medicine suggests common symptoms such as muscle pain and weakness are not caused by the drugs themselves Getty 36/47 Babies born to fathers aged under 25 have higher risk of autism New research has found that babies born to fathers under the age of 25 or over 51 are at higher risk of developing autism and other social disorders. The study, conducted by the Seaver Autism Center for Research and Treatment at Mount Sinai, found that these children are actually more advanced than their peers as infants, but then fall behind by the time they hit their teenage years. 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They asked half of the patients to briefly recall the incident and then play the classic computer game, the others were given a written activity to complete. The researchers, from Karolinska Institute in Sweden and the University of Oxford, found that the patients who had played Tetris reported fewer intrusive memories, commonly known as flashbacks, in the week that followed Rex 39/47 Vaping backed as healthier nicotine alternative to cigarettes after latest study Vaping has been given an emphatic thumbs up by health experts after the first long-term study of its effects in ex-smokers. After six months, people who switched from real to e-cigarettes had far fewer toxins and cancer-causing substances in their bodies than continual smokers, scientists found Matt Cardy/Getty Images 40/47 Common method of cooking rice can leave traces of arsenic in food, scientists warn Millions of people are putting themselves at risk by cooking their rice incorrectly, scientists have warned. Recent experiments show a common method of cooking rice — simply boiling it in a pan until the water has steamed out — can expose those who eat it to traces of the poison arsenic, which contaminates rice while it is growing as a result of industrial toxins and pesticides Getty 41/47 Contraceptive gel that creates ‘reversible vasectomy’ shown to be effective in monkeys An injectable contraceptive gel that acts as a ‘reversible vasectomy’ is a step closer to being offered to men following successful trials on monkeys. Vasalgel is injected into the vas deferens, the small duct between the testicles and the urethra. It has so far been found to prevent 100 per cent of conceptions Vasalgel 42/47 Shift work and heavy lifting may reduce women’s fertility, study finds Women who work at night or do irregular shifts may experience a decline in fertility, a new study has found. Shift and night workers had fewer eggs capable of developing into healthy embryos than those who work regular daytime hours, according to researchers at Harvard University Getty 43/47 Japanese government tells people to stop overworking The Japanese government has announced measures to limit the amount of overtime employees can do – in an attempt to stop people literally working themselves to death. A fifth of Japan’s workforce are at risk of death by overwork, known as karoshi, as they work more than 80 hours of overtime each month, according to a government survey. Getty 44/47 High blood pressure may protect over 80s from dementia It is well known that high blood pressure is a risk factor for dementia, so the results of a new study from the University of California, Irvine, are quite surprising. The researchers found that people who developed high blood pressure between the ages of 80-89 are less likely to develop Alzheimer’s disease (the most common form of dementia) over the next three years than people of the same age with normal blood pressure. Getty 45/47 'Universal cancer vaccine’ breakthrough claimed by experts Scientists have taken a “very positive step” towards creating a universal vaccine against cancer that makes the body’s immune system attack tumours as if they were a virus, experts have said. Writing in Nature, an international team of researchers described how they had taken pieces of cancer’s genetic RNA code, put them into tiny nanoparticles of fat and then injected the mixture into the bloodstreams of three patients in the advanced stages of the disease. The patients' immune systems responded by producing "killer" T-cells designed to attack cancer. The vaccine was also found to be effective in fighting “aggressively growing” tumours in mice, according to researchers, who were led by Professor Ugur Sahin from Johannes Gutenberg University in Germany Rex 46/47 Research shows that diabetes drug can be used to stop first signs of Parkinson’s Scientists in a new study show that the first signs of Parkinson’s can be stopped. The UCL study is still in its research period but the team are ‘excited’. Today’s Parkinson’s drugs manage the symptoms of the disease but ultimately do not stop its progression in the brain. PA 47/47 Drinking alcohol could reduce risk of diabetes A new study shows that drinking alcohol three to four days a week could reduce the risk of diabetes. Wine was found to be most effective in reducing the risk due to the chemical compounds that balance blood sugar levels. Getty

Alongside her extensive medical history, the authors said: “She reported numerous burns and cuts without pain, often smelling her burning flesh before noticing any injury, and these wounds healed quickly with little or no residual scar.”

In tests she could also eat fiery Scotch bonnet chillis “without any discomfort, but a short-lasting ‘pleasant glow’ in her mouth”.

“I had no idea until a few years ago that there was anything that unusual about how little pain I feel – I just thought it was normal," Ms Cameron said.

"Learning about it now fascinates me as much as it does anyone else.”

Referring her to pain geneticists at University College London and the University of Oxford they identified two mutations of note. One in a gene called Faah (Fatty Acid Amide Hydrolase), which is well known to pain researchers.

The FAAH gene plays a role in the body’s endocannabinoid system, the parts of the central nervous system which play a role in pain, memory and mood and which the compounds in cannabis act on.

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They also found a second gene, which had previously been written off as “junk DNA” with no useful purpose. It now appears this gene, which they dubbed “Faah-Out”, controls the Faah gene and in Ms Cameron switches it off.

As well as her wound healing and pain insensitivity the woman scored a zero in tests of anxiety and depression, and said she never panics in dangerous situations – like in a recent car accident.

If there is any kryptonite (apart from occasionally smelling your own sizzling flesh) it is that she was moderately absent minded and has always been prone to forgetting keys or losing her train of thought.

“The implications for these findings are immense,” said Dr Devjit Srivastava, the Raigmore pain consultant who diagnosed her.

Half of patients recovering from surgery still experience moderate to severe pain, despite modern painkillers.

It could be the case that the Faah-Out gene is the key to unlocking the pain reducing potential of the Faah gene where other attempts have failed.

“The findings point towards a novel pain killer discovery that could potentially offer post-surgical pain relief and also accelerate wound healing,” Dr Srivastava said.

“We hope this could help the 330 million patients who undergo surgery globally every year.”

Ms Cameron said she would "be elated if any research into my own genetics could help other people who are suffering,”

There could be many more people living with this mutation unnoticed and they appealed for more people to come forward as it could help drive these research efforts on.

Kevin_Post_Malone on September 7th, 2019 at 18:12 UTC »

The title is bullshit. If you read the actual research paper, it says "she reported that these wounds healed quickly with little or no residual scar." However, "on clinical examination, she had multiple scars around the arms and on the back of her hands". So she can't actually heal without scarring. She just thought she could.

Source: https://www.sciencedirect.com/science/article/pii/S0007091219301382

Im_Not_Jeb on September 7th, 2019 at 15:09 UTC »

The lack of pain is a problem, but the 'heals without scarring'... that woman should be getting millions from the medical industry to be a professional research subject for the rest of her life (or until they figure out how that works).

kjwinter on September 7th, 2019 at 15:08 UTC »

Keep House away from her.