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This is the first DRCT to demonstrate that consumption of gluten-containing flour does not generate symptoms in healthy volunteers. The trial measured how daily ingestion of the flour (containing 14 g of gluten) affected a range of symptoms over 2 weeks, none of which significantly changed between groups. Within-group analyses similarly produced no significant findings, other than one indication that symptoms of diarrhea improved in the gluten group (likely anomalous and in any case does not support that the flour caused symptoms).
Our results support the view that gluten does not appear to cause symptoms in individuals who do not have a physiological susceptibility to it (ie, most of the population). As the GFD is not only thought to be no healthier than a “normal” diet, but has been suggested as overall suboptimal,1x1Niland, B. et al. Gastroenterol Hepatol. ; 14: 82–91
Google ScholarSee all References there is possibly clinical justification in actively discouraging people from starting it if they have no diagnosable sensitivity.
A potential study limitation is the relatively short duration of the trial, although other DRCTs in NCGS indicate onset of symptoms can begin after 1 week.7x7Shahbazkhani, B. et al. Nutrients. ; 7: 4542–4554
Crossref | PubMed | Scopus (61) | Google ScholarSee all References Another consideration is that the study topic may have unintentionally attracted participants with NCGS/irritable bowel syndrome; however, the presence of these would likely bias the study toward positive findings, so confidence in the null results should remain high.
Patients who self-report symptoms related to gluten must have CD and NCGS excluded, but on the basis of these new data perhaps the assertion by “lifestylers” that a GFD is beneficial can also be challenged.
tarzan322 on August 27th, 2019 at 12:13 UTC »
While it may not cause issues in healthy people, there are plenty of unhealthy people. People with Celiacs Disease are said to be the only ones that may suffer from gluten sensitivities, but I feel there may be more to it.
People with Celiacs Disease are one of seven groups of people who's disease is linked to Eppstien Barr, or more commonly called Mononucleosis. These diseases also include systemic lupus erythematosus, multiple sclerosis, rheumatoid arthritis, juvenile idiopathic arthritis, inflammatory bowel disease, and Type 1 diabetes.
While these other diseases are not commonly known to have gluten allergies, it may be possible that sufferers of these diseases may benifit from or feel relief from gluten free diets. Inflammation is a common sign of all these sufferers. This could also help explain why going gluten free has become as big as it has, as reports probably have only listed Celiacs sufferers as the only beneficiaries of gluten free. Further research should be done to see if going gluten free could be a benifit to sufferers of these other diseases, who are not at all healthy.
https://www.usnews.com/news/health-care-news/articles/2018-04-16/study-mono-virus-linked-to-7-other-serious-diseases
DrBix on August 27th, 2019 at 11:31 UTC »
Test size was only 30 people. Is that enough to make a thorough analysis and conclusion? Not a medical person, just wondering. I'm used to reading papers that have a much, much, larger subject base.
Cracker77 on August 27th, 2019 at 04:12 UTC »
This is relevant. https://www.washingtonpost.com/lifestyle/wellness/fructans-not-gluten-might-cause-wheat-sensitivity-heres-what-you-need-to-know/2018/11/05/fcee5f2c-dbb3-11e8-b3f0-62607289efee_story.html