New research indicates that psilocybin-assisted mindfulness meditation is associated with changes in functional brain connectivity — and these changes are related to an altered state of consciousness known as ego dissolution.
A team of scientists from the University of Zurich were interested in investigating the topic because both psychedelic drugs and meditation have been shown to alter brain regions involved in self-awareness.
In the randomized, double-blind study of 38 experienced meditators, the researchers administered a single dose of psilocybin or a placebo to participants during a 5-day mindfulness retreat.
Six hours after receiving psilocybin or placebo, the participants completed an assessment of altered states of consciousness.
The researchers found that this altered state of consciousness was associated with changes in brain connectivity.
Psilocybin-induced ego dissolution and changes in brain connectivity also predicted positive changes in attitudes about life, self, social behavior, mood, and spirituality at a 4 months follow-up assessment.
The results are largely in line with a previous study that examined the combination of psilocybin and meditation. »