Lawyers who represented Epstein did not immediately respond on Friday to requests for comment.
The plaintiffs, identified as Jane Doe 1 and Jane Doe 2, said they now live in Okinawa, Japan and Baltimore.
Prior to his death, Epstein had pleaded not guilty in July to charges of sex trafficking involving dozens of underage girls from 2002 and 2005.
Epstein’s death deprived his alleged victims of a chance to face him at a criminal trial, leaving civil lawsuits against his estate among their legal options.
The plaintiffs said they were unaware they were victims of Epstein’s alleged sex-trafficking scheme until last month when he was arrested.
That lawsuit was made possible under the Child Victims Act, a New York state law that opened a one-year window to sue over alleged sexual abuse, regardless of when it occurred.
Thursday’s lawsuit, in contrast, accused Epstein, Sue Roe and other unnamed alleged accomplices of violating the federal Trafficking Victims Protection Act. »