Currently, many vaccines have to be manufactured in cell culture or eggs, which is expensive and carries the risk of contaminations.
In tropical and subtropical regions, such cold storage requirements could contribute to more than 80 percent of the vaccine cost.
“Importantly, this vaccine technology could potentially serve as a universal platform for development of live-attenuated vaccines for many viral pathogens.”.
Because DNA molecules are shelf stable, the vaccine will not expire at warm temperatures and could be stockpiled at room temperature for years.
Using UTMB’s Zika vaccine as a model, the research group showed that the DNA platform worked very efficiently in mice.
“We will continue testing this promising Zika vaccine platform and then apply the platform to other viruses.”.
Other authors include UTMB’s Jing Zou, Xuping Xie, Huanle Luo, Chao Shan, Antonio Muruato, Scott Weaver and Tian Wang. »