Brian Gordon, Tyler Blazey, and colleagues at Washington University in St. Louis reported that this cascade emanated from the precuneus.
In general, Aβ accumulated first, then metabolism waned, then the cortex thinned, though some regions deviated from this sequence.
The precuneus succumbed first, accumulating Aβ more than 20 years before symptoms.
“[It] challenges us to look more closely at regional differences in the temporal time line of biomarkers,” she added.
Affected members develop early onset AD at an age researchers can predict based on family history and mutation.
The researchers fed both serial and cross-sectional data into a Bayesian statistical model to calculate annual rates of change for each marker.
Though Aβ deposition appeared long before the drop in glucose uptake in Gordon’s study, the researchers did not assess aerobic glycolysis specifically. »