The Daily Populous

Wednesday November 8th, 2017 day edition

image for Single-Dose Oral Opioid and Nonopioid Analgesics for Acute Extremity Pain

Question Do any of 4 oral combination analgesics (3 with different opioids and 1 opioid-free) provide more effective reduction of moderate to severe acute extremity pain in the emergency department (ED)?.

Findings In this randomized clinical trial of 411 ED patients with acute extremity pain (mean score, 8.7 on the 11-point numerical rating scale), there was no significant difference in pain reduction at 2 hours.

Mean pain scores decreased by 4.3 with ibuprofen and acetaminophen (paracetamol); 4.4 with oxycodone and acetaminophen; 3.5 with hydrocodone and acetaminophen; and 3.9 with codeine and acetaminophen.

Meaning For adult ED patients with acute extremity pain, there were no clinically important differences in pain reduction at 2 hours with ibuprofen and acetaminophen or 3 different opioid and acetaminophen combination analgesics.

Importance The choice of analgesic to treat acute pain in the emergency department (ED) lacks a clear evidence base.

Main Outcomes and Measures The primary outcome was the between-group difference in decline in pain 2 hours after ingestion.

Pain intensity was assessed using an 11-point numerical rating scale (NRS), in which 0 indicates no pain and 10 indicates the worst possible pain. »

Snap lost nearly $40 million on unsold Spectacles

Authored by theverge.com

Packaged in its statement was a tiny nugget of news regarding the company’s Spectacles, the camera-equipped sunglasses it sells both online and in pop-up vending machines around the world.

Snap says it lost nearly $40 million on the device, “primarily related to excess inventory reserves and inventory purchase commitment cancellation charges.”.

Snap is still reportedly working on more fully featured AR glasses, but The Information reported that it’s since scrapped its drone project amid the hardware struggles with Spectacles. »

Farmers must stop antibiotics use in animals due to human health risk, warns WHO

Authored by theguardian.com

Overuse of antibiotics in animals is contributing to growing drug resistance in humans with serious health implications, says global health body.

Using antimicrobial medicines on farm animals is one of the leading causes of the rise of superbugs, resistant to all but the strongest antibiotics.

Even in some countries where routine use for enhancing growth is banned, more antibiotics are used on animals than on humans. »

Updated: Danica Roem Becomes Virginia's First Transgender State Legislator

Authored by nbcnews.com
image for

Democrat Danica Roem became the first transgender person to be elected to Virginia's state legislature on Tuesday after defeating a 13-term member of Virginia's House of Delegates.

Once she is sworn in in January, she will be the first openly transgender legislator seated.

Stacie Laughton, who is openly transgender, was elected to the New Hampshire House of Representatives in 2012. »

Disney Ends Ban on Los Angeles Times Amid Fierce Backlash

Authored by nytimes.com

On Tuesday, members of the Los Angeles Film Critics Association, the New York Film Critics Circle, the Boston Society of Film Critics and the National Society of Film Critics denounced Disney’s blackout of The Los Angeles Times.

The Los Angeles Times responded at the time by saying that Disney had not asked for any corrections.

The New York Times also joined the boycott on Tuesday, before Disney lifted the ban, saying in a statement that it would “not attend preview screenings for Disney movies until access is restored to the Los Angeles Times.”. »